Subchronic Toxicological Evaluation of Eupatorium Aschenbornianum in Wistar Rats

Eupatorium aschenbornianum is a plant used for the treatment of gastric ulcer, therefore, the present study aimed to evaluate the safety of this dehydrated plant in order to find the appropriate doses for further human studies. Male Wistar rats were fed with different incremental doses dehydrated plant from 200 to 1000 mg/kg bw in a subchronic test during 45 days. Animals were sacrificed, then the clinical, hematological and biochemical changes were assessed and compared with the control group. The behavior, weight and feed consumption of the rats was normal. Also the biochemical parameters were normal except the uric acid and glutamic oxaloacetic transaminase showing elevated levels in the group treated with the highest dose. The dose of 800 mg/kg bw could be considered as no observed adverse effect level and could be used in further clinical trials in a safe manner.